12, 15, 24, 26– 29 Thus, an assessment of sNfL levels at baseline and over the course of long-term treatment may provide a more sensitive measure of treatment effectiveness than clinical or MRI measures alone and can help to inform whether baseline sNfL levels predict treatment outcomes. 12– 14, 16– 25 sNfL levels have also been shown to decline in response to treatment with MS disease-modifying therapies (DMTs). 11– 13 In patients with MS, higher serum NfL (sNfL) levels are associated with greater clinical and MRI measures of disease activity 12, 14, 15 and may predict worse long-term clinical and MRI outcomes. 6, 7 NfL has been proposed as a prognostic biomarker for MS 8– 10 and as a biomarker for MS disease activity and treatment response.
4 Elevated levels of NfL have been detected in neurodegenerative diseases, 2, 5 including MS. Neurofilament light chain (NfL) is an axonal cytoskeletal protein that is released into the extracellular space following neuronal injury, such as brain trauma. All subjects Allied Health Cardiology & Cardiovascular Medicine Dentistry Emergency Medicine & Critical Care Endocrinology & Metabolism Environmental Science General Medicine Geriatrics Infectious Diseases Medico-legal Neurology Nursing Nutrition Obstetrics & Gynecology Oncology Orthopaedics & Sports Medicine Otolaryngology Palliative Medicine & Chronic Care Pediatrics Pharmacology & Toxicology Psychiatry & Psychology Public Health Pulmonary & Respiratory Medicine Radiology Research Methods & Evaluation Rheumatology Surgery Tropical Medicine Veterinary Medicine Cell Biology Clinical Biochemistry Environmental Science Life Sciences Neuroscience Pharmacology & Toxicology Biomedical Engineering Engineering & Computing Environmental Engineering Materials Science Anthropology & Archaeology Communication & Media Studies Criminology & Criminal Justice Cultural Studies Economics & Development Education Environmental Studies Ethnic Studies Family Studies Gender Studies Geography Gerontology & Aging Group Studies History Information Science Interpersonal Violence Language & Linguistics Law Management & Organization Studies Marketing & Hospitality Music Peace Studies & Conflict Resolution Philosophy Politics & International Relations Psychoanalysis Psychology & Counseling Public Administration Regional Studies Religion Research Methods & Evaluation Science & Society Studies Social Work & Social Policy Sociology Special Education Urban Studies & Planning BROWSE JOURNALS
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